PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease
نویسندگان
چکیده
منابع مشابه
The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
A sequence variation (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism remains obscure. In this study, we used knock-in (KI) mice (Pnpla3148M/M ) to examine the mechanism responsible for accumulation of triglyceride (TG) and PNPLA3 in hepatic lipid droplets (LDs). No differences were found bet...
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ژورنال
عنوان ژورنال: Digestive and Liver Disease
سال: 2013
ISSN: 1590-8658
DOI: 10.1016/j.dld.2012.12.006